Correspondence: G van Echten-Deckert, LIMES Institute Membrane Biology and Lipid Biochemistry, University of Bonn, Bonn 53121, Germany.Tel: 49 228 73 2703; Fax: 49 288 73 4845; E-mail: [email protected] 16 July 2010; Revised 16 December 2010; Accepted 3 January 2011; Published online 18 February 2011.Edited by M Deshmukh We have recently reported that the bioactive lipid sphingosine-1-phosphate (S1P), usually signaling proliferation and anti-apoptosis induces neuronal death when generated by sphingosine-kinase2 and when accumulation due to S1P-lyase deficiency occurs.In the present study, we identify the signaling cascade involved in the neurotoxic effect of sphingoid-base phosphates.Neuroanatomical studies in the cerebellum document for the first time that indeed neurons with abundant S1P-lyase expression are those, which degenerate first in S1P-lyase-deficient mice.We therefore propose that an impaired metabolism of glycosphingolipids, which are prevalent in the central nervous system, might be linked via S1P, their common catabolic intermediate, to neuronal death.We and our guests discuss relationships and health and wellness, each of which contributes to meaningful and fulfilling lives. I’m the Founder of Intersections Match, the only elite national personalized matchmaking company focused on singles of South Asian descent nationwide in the US. As a professional dating coach and matchmaker to successful men and women, I’m fascinated by insights supporting people’s efforts to evolve into the best versions of their authentic selves.
_____ Jasbina Ahluwalia (): Hello everyone and welcome to Intersections Match’s Talk Radio, a monthly holistic lifestyle show focused on the continual evolution into the best versions of our authentic selves. AD, Alzheimer's disease; CCCP, carbonyl-cyanide m-chlorophenyl hydrazone; CDK5, cyclin-dependent kinase5; cimes, cis-4-methylsphingosine; cimes P, cis-4-methylsphingosine-phosphate; ER, endoplasmic reticulum; SK, sphingosine-kinase; S1P, sphingosine-1-phosphate; Rb, retinoblastoma protein Gangliosides, a class of sialic acid containing complex glycosphingolipids are characteristic components of neuronal cells.Neuronal ganglioside profiles vary in different regions of the brain and characteristically change during ontogenesis.According to the release, Deutsche Bank and various senior managers missed key opportunities to detect, intercept and investigate the mirror scheme.The release provided the following details of the operation: “Operating through the equities desk at Deutsche Bank’s Moscow branch, certain companies that were clients of the Moscow equities desk issued orders to purchase Russian blue chip stocks, always paying in rubles.Over the last 20 years, David has become one of the most frequently-quoted dating experts in the media.